The Pros and Cons of Ozempic Weight Loss Drugs for Perimenopausal Women
In this blog we explore Ozempic, hailed as the miracle weight loss drug. We look at the pros and cons and why it’s might not be the quick fix you thought it was.
(and why you might want to do your research before taking this drug for weight loss)
Perimenopause, the transitional phase before menopause, typically occurs in women aged 40 to 55 and is characterised by hormonal fluctuations that can lead to weight gain, particularly around the abdomen.
Weight management during this period is crucial, as excess weight can exacerbate symptoms such as hot flashes, mood swings and increase the risk of chronic diseases like cardiovascular disease, type 2 diabetes and stroke.
Recently, weight loss drugs like Ozempic (semaglutide) and others have gained attention for their potential to help with weight management. This blog explores the scientific evidence behind the use of these drugs, focusing on their pros and cons for perimenopausal women looking to lose weight.
About Ozempic (Semaglutide):
Originally developed to treat type 2 diabetes, Ozempic is a GLP-1 receptor agonist that mimics the hormone GLP-1, which helps regulate appetite and insulin levels.
In higher doses (2.4 mg), semaglutide is marketed as Wegovy for chronic weight management.
It works by slowing gastric emptying, reducing appetite, and promoting a feeling of fullness, leading to reduced caloric intake.
Pros of Using Weight Loss Drugs in Perimenopausal Women
1. Effective Weight Management:
Clinical studies have shown that drugs like Ozempic can lead to significant weight loss. A 2021 trial demonstrated that semaglutide could reduce body weight by approximately 14.9% in participants, including women, over a 68-week period .
Weight loss can alleviate some perimenopausal symptoms like hot flashes, and reduce the risk of developing type 2 diabetes, hypertension, and cardiovascular diseases .
2. Improvement in Metabolic Health:
Beyond weight loss, GLP-1 receptor agonists like semaglutide have been shown to improve markers of metabolic health, including blood glucose levels, insulin sensitivity, and lipid profiles, all of which can change during perimenopause.
This is particularly beneficial for perimenopausal women who may experience an increased risk of insulin resistance and metabolic syndrome during this phase .
3. Reduced Appetite and Caloric Intake:
The appetite-suppressing effects of these drugs can be particularly helpful in managing the increased hunger and cravings that some women experience during perimenopause due to fluctuating hormone levels.
4. Psychological Benefits:
Weight loss can lead to improved self-esteem and body image, which are important aspects of mental health, particularly during the challenging perimenopausal transition where we are dealing with the changes of perimenopause.
Cons of Using Weight Loss Drugs in Perimenopausal Women
1. Side Effects:
Common side effects of Ozempic and similar drugs include gastric issues, nausea, vomiting, diarrhea, and constipation, which can be severe enough to lead some users to discontinue the drug .
There is also concern about the long-term safety of these drugs, particularly in relation to their effects on the pancreas and gallbladder, as some studies suggest an increased risk of pancreatitis and gallbladder disease .
2. Cost:
These medications can be expensive, which may be a barrier for many women who are not eligible for treatment on the NHS.
3. Long-term Dependence:
There is a risk of regaining weight after discontinuing these drugs, as they do not address the underlying causes of weight gain, such as lifestyle factors and hormonal changes, nutrition and exercise. This may lead to long-term dependence on the medication to maintain weight loss. It is really important that Women address their nutrition and lifestyle even if they decide to undergo treatment with Ozempic. Weight loss drugs are not a cure, simply they aid in getting you started. If you do not address the basics of good health the weight will return.
4. Potential Impact on Bone Health:
Some studies suggest that rapid weight loss, particularly in older women, could lead to a reduction in bone density, increasing the risk of osteoporosis—a significant concern for perimenopausal women . There is also emerging research that weight loss drugs contribute to sarcopenia (loss of muscle) which is already an issue as we age and can cause issues later in life.
5. Contraindications and Cautions:
Women with a history of certain medical conditions, such as thyroid cancer or pancreatitis, may be advised against using GLP-1 receptor agonists. Additionally, the safety of these drugs during perimenopause, a time of significant hormonal change, has not been thoroughly studied and we still have a lot of research to do with regards to Ozempic as a tool for weight loss. There has also been concerns about a shortage of the drug, which is essential for many diabetics, because of the use of it for weight loss.
Conclusion
Weight loss drugs like Ozempic and others offer promising benefits for perimenopausal women struggling with weight management. They can lead to significant weight loss, improve metabolic health, and provide psychological benefits. However, these advantages must be weighed against potential side effects, costs, and the need for long-term use.
Perimenopausal women considering these medications should consult with their health practitioner to discuss their individual health needs, potential risks, and the most appropriate weight management strategy for them, which should always include lifestyle modifications like diet and exercise. During this stage of life it is imperative we are managing our longterm health and Ozempic could actually exaggerate symptoms already caused by peri menopause.
In my opinion weight loss drugs should only be considered as an absolute last resort and should be administered alongside a proper program to improve nutrition, exercise and lifestyle habits to support and maintain any results once treatment finishes.
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